Surprisingly, pre-40S particles containing 20S pre-rRNA form translation-competent 80S ribosomes, and translation inhibition partially suppresses 20S pre-rRNA accumulation. This was not seen for other mutations in or depletion of 元 or other 60S ribosomal proteins. We report that the rpl3 allele, which affects the affinity and function of translation elongation factors, impairs cytoplasmic maturation of 20S pre-rRNA. Ribosomal protein 元 is an evolutionarily conserved protein that participates in the assembly of early pre-60S particles.
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